The main caveat with Affinity is that its bonuses are not defined and the stat itself goes completely unexplained in-game
There are restrictions on the S materials, but with the "Graydle" Deck, you can use the effect of "Graydle Slime Jr.", and with the "Fish" Deck, you can combine Royal Swamp Eel, Double Fin Shark, and Silent Angler, so I don't think there's a problem
For instance, Patchwork Beastie will be able to attack, Impossible Inferno will exile cards off the top of your library, and Scuttletide will give Crabs you control +1/+1
Even if you don't reach the $25,000 level throughout the game, you get to keep any $1,000 tokens you earned from players using your correct answers to save themselves