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is α7 nicotinic acetylcholine receptor positive allosteric modulator
InChi: InChI=1S/C19H27N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4
Smiles: OC1C=C2C3C4C(OC2=O)=C(O)C(O)=CC=4C(=O)OC=3C=1O
and has no effects for CYP2C8-mediated M3 formation
CBR-5884 nib (EGF816) is α7 nicotinic acetylcholine receptorCBR 5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 M. CBR 5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR 5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Product information CAS Number: 681159 27 3 Molecular Weight: 336. 39
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