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28)29)32-22(36)39/h7-9
3⁵]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-3
GSK040 shows more than 5000-fold selectivity for BET BD2 over BET BD1 (pIC50=4
CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity
Tankyrase Inhibitors (TNKS) 49 Size:Contact [email protected] for quotation 28)29)32-22(36)39/h7-9Tankyrase Inhibitors (TNKS) 49 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis
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