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SC-514 inhibits transcription of NF-κB-dependent genes in IL-1β-induced rheumatoid arthritis-derived synovial fibroblasts in a dose-dependent manner
with an IC50 of 4 μM
291:137-143
InChi: InChI=1S/C51H63F2N11O10/c1-54-51(70)61-17-11-41-40(31-61)47(62-14-3-4-32-26-37(33-29-56-59(2)30-33)38(46(52)53)28-43(32)62)58-64(41)35-9-15-60(16-10-35)45(66)12-18-71-20-22-73-24-25-74-23-21-72-19-13-55-34-5-6-36-39(27-34)50(69)63(49(36)68)42-7-8-44(65)57-48(42)67/h5-6
SCO-267 drograpanin SC-514 inhibits transcription of NF-κB-dependentSCO 267 is an allosteric GPR40 full agonist. SCO 267 can be used for the research of chronic diseases including diabetes. Product information CAS Number: 1656261 09 4 Molecular Weight: 614. 77 Formula: C36H46N4O5 Chemical Name: (3S) 3 cyclopropyl 3 {2 [(1 {2 [(2, 2 dimethylpropyl)(6 methylpyridin 2 yl)carbamoyl] 5 methoxyphenyl}piperidin 4 yl)methoxy]pyridin 4 yl}propanoic acid Smiles:
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