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checkpoint Kinase 2 (Chk2) activation
CAS Number: 1279031-70-7
oral administration of 3-chloro-5-hydroxybenzoic acid at 30 mg/kg provided a Cmax of 67 μM at approximately 3-fold over the in vitro EC50 with an AUCinf of 54 h μM and a short t1/2 of 1
Formula: C22H27FN4O2
VP-14637 coidan checkpoint Kinase 2 (Chk2) activationEC50: 5. 4 nM for RSV fusion VP 14637 is an inhibitor of RSV. Respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. RSV F protein that mediates fusion of the viral envelope with the host cell membrane has become a target of anti RSV treatment. In vitro: Previous study demonstrated that VP 14637 did not block RSV adsorption but inhibited RSV induced cell cell fusion and specifically bound to RSV infected
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