Ketoconazole-d8 - CAS# 1217706-96-1 tetrazine-PEG5-NHS ester Smiles: CC(C)C[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC3=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N2)[C@@H](C)O)[C@@H](C)O

Smiles: CC(C)C[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC3=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N2)[C@@H](C)O)[C@@H](C)O

The iberin-induced apoptosis is found to be associated with activation of caspase-9

The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation

GDC-0310 exhibits t1/2 values of 5 h

Ketoconazole-d8 - CAS# 1217706-96-1 tetrazine-PEG5-NHS ester Smiles: CC(C)C[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC3=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N2)[C@@H](C)O)[C@@H](C)OKetoconazole d8 is the deuterium labeled Ketoconazole. Ketoconazole (R 41400) is an imidazole anti fungal agent, a CYP3A4 and CYP24A1 inhibitor. Product information CAS Number: 1217706 96 1 Molecular Weight: 539. 48 Formula: C26H28Cl2N4O4 Chemical Name: 1 [4 (4 {[(2R,4S) 2 (2,4 dichlorophenyl) 2 [(1H imidazol 1 yl)methyl] 1,3 dioxolan 4 yl]methoxy}phenyl)(2,2,3,3,5,5,6,6 H)piperazin 1 yl]ethan 1 one Smiles: