C1CC1)[C@H]1CC[C@H]2/C(/CCC[C@@]21C)=C/C=C1/C[C@@H](O)C[C@H](O)C/1=C](https://cdn.shopify.com/s/files/1/0389/1897/9723/files/1690524027259_1.png?v=1690524045)
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Smiles: C[C@H](CC[C@H](O)C1CC1)[C@H]1CC[C@H]2/C(/CCC[C@@]21C)=C/C=C1/C[C@@H](O)C[C@H](O)C/1=C
thus does not possess mGlu5 NAM activity
Smiles: O=C(NC1=NC=C(CCNC2=NC=NC3C=CSC=32)S1)NC1=CC(Cl)=CC=C1
Formula: C129H230N36O29S
NB-598 Hydrochloride alafenamide hemifumarate Smiles: C[C@H](CC[C@H](O)C1CC1)[C@H]1CC[C@H]2/C(/CCC[C@@]21C)=C/C=C1/C[C@@H](O)C[C@H](O)C/1=CNB 598 is a potent competitive inhibitor of squalene epoxidase (SE). NB 598 suppresses triglyceride biosynthesis through the farnesol pathway. NB 598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB 598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB 598 suppressed the basolateral secretion of apolipoprotein (apo) B.