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Treatment of MCL cell lines with EPZ015666 led to inhibition of SmD3 methylation and cell death
prevents DNA-TLR9 interaction in vitro and modulates signaling in vivo
4-dihydro-1H-isoquinolin-2-yl]methanone
(2011) Cancer Lett
N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 Treatment of MCL cell linesN106, CAS No. 862974 25 2, is a potent SERCA2a SUMOylation activator, which increases SUMOylation of SERCA2a. Decreased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a critical pump regulating calcium cycling in cardiomyocyte, are hallmarks of heart failure. The small ubiquitin like modifier type 1 (SUMO 1) is a regulator of SERCA2a and the gene transfer of SUMO 1 in rodents and large animal models of heart
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