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and promising in vivo antitumor efficacy
PubMed Central PMCID: PMC2791573
2265-64-7 (Dexamethasone isonicotinate)
(2001) 14 226
CCG-63808 metabolite Hydroxy Iloperidone and promising in vivo antitumorCCG 63808 is a potent and reversible RGS protein inhibitor. Regulators of G protein signalling (RGS) are major determinants of metabotropic receptor activity, reducing the lifespan of the GTP bound state of G proteins. Inhibition of spinal RGS4 restored endogenous analgesic signalling pathways and mitigated neuropathic pain. Signalling through CB1 receptors may be involved in this beneficial effect. Product information CAS Number: 620113 73 7
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