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4R)-1-[(2S)-2-(2-{2-[2-({4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3
MI-2 was used at 10-25 µM concentration in vitro and in the cellular assays
Exp Eye Res
Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion
Mutant IDH1-IN-4 terhydrate 4R)-1-[(2S)-2-(2-{2-[2-({4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3Mutant IDH1 IN 4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of 0. 5 M for mutant IDH1 in R132H, HT1080 and U87R132H cells. Product information CAS Number: 1416270 18 2 Molecular Weight: 438. 56 Formula: C25H34N4O3 Chemical Name: 8 cyclopropyl 6 [(3R) 3 cyclopropyl 4 (3 methoxypropanoyl)piperazin 1 yl] 3,3 dimethyl 1H,3H,4H pyrano[3,4 c]pyridine 5 carbonitrile Smiles:
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