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CO-1686 (100 mg/kg/day
and by allergen (dust mite) in basophils (histamine release
2(6):799-803
25 days) suppresses cytochrome P450 1A1 expression and the intrahepatocyte fat content in liver
YM-201636 - CAS# 371942-69-7 size:2mg solid CO-1686 (100 mg/kg/dayYM 201636, CAS No. 371942 69 7, is an inhibitor of retroviral budding and PIKfyve catalyzed PtdIns(3, 5)P2 synthesis, and can also halt glucose entry by insulin in adipocytes. YM 201636 almost completely inhibited basal and insulin activated 2 deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+ 4 nM for the net insulin response. Insulin induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those
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