Hypothemycin Size:2mg solid 6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-[(1

6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-[(1

Exp Eye Res

9bS)-9-hydroxy-6

TL12-186 is a multikinase degrading PROTAC

Hypothemycin Size:2mg solid 6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-[(1Hypothemycin, a fungal polyketide, is a multikinase inhibitor with Kis of 10 70 nM, 17 38 nM, 90 nM, 900 nM 1. 5 M, and 8. 4 2. 4 M for VEGFR2 VEGFR1, MEK1 MEK2, FLT 3, PDGFR PDGFR, and ERK1 ERK2, respectively. Product information CAS Number: 76958 67 3 Molecular Weight: 378. 37 Formula: C19H22O8 Chemical Name: (2R, 4R, 6S, 7S, 12S) 6, 7, 16 trihydroxy 18 methoxy 12 methyl 3, 13 dioxatricyclo[13. 4. 0. 0, ]nonadeca 1(19), 9, 15, 17 tetraene 8, 14