TAK-659 3992 5-dimethylphenyl)carbamoyl]amino}phenyl sulfamate

5-dimethylphenyl)carbamoyl]amino}phenyl sulfamate

3 hours after MCAO) at the time of ischemia onset also dose-dependently reduced infarct size

reducing capabilities and Fe2+ chelating effects

PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase

TAK-659 3992 5-dimethylphenyl)carbamoyl]amino}phenyl sulfamateTAK 659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3. 2 nM and 4. 6 nM for SYK and FLT3, respectively. TAK 659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL). Product information CAS Number: 1312691 33 0 Molecular Weight: 344. 39 Formula: