TH588 - MTH1 Inhibitor. CAS# 1609960-31-7 Catalog No.:M60211-10S suggesting the involvement of histone

suggesting the involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency

Chemical Name: (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1

is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3

2'-bioxolan]-5-yl]-9-hydroxy-2

TH588 - MTH1 Inhibitor. CAS# 1609960-31-7 Catalog No.:M60211-10S suggesting the involvement of histoneTH588, CAS No. 1609960 31 7, is a novel potent, selective and cell permeable inhibitor of the nudix hydrolase family MTH1 protein with an IC50 of ~5 nM. Protein co crystal structures demonstrate that TH588 binds in the active site of MTH1. It has excellent selectivity over other nudix family proteins and kinases present in the selectivity panel. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA