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PX-478 was used at 1-10 µM final concentration in various in vitro assays
20-triene-3
CAS Number: 18085-97-7
InChiKey: VYGQUTWHTHXGQB-FFHKNEKCSA-N
Lysine-specific Demethylase Inhibitor (1C) orine hydrochloride PX-478 was used at 1-10Lysine specific Demethylase Inhibitor (1C) is a lysine specific demethylase inhibitor. Lysine specific demethylase 1 (LSD1) is the first of several protein lysine demethylases identified. Through a FAD dependent oxidative reaction, LSD1 could specifically remove histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor, LSD1 alters its substrates to H3K9me2. The LSD1 complex regulates a coordinated histone modification
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