Indirubin 0156 UNC6852 is a selective degrader

UNC6852 is a selective degrader that targets polycomb repressive complex 2 (PRC2) with IC50 of 247 nM for EED

It has no activity on the related receptors ERRα

and may be new candidate for glima treatment in the clinic

but does not exert such an effect in SW620 cells[1]

Indirubin 0156 UNC6852 is a selective degraderIndirubin is a potent and selective CDK inhibitor. Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. Indirubin has been used to treat the symptoms of leukemia. Further biological explorations revealed the ability of indirubin to bind cyclin dependent kinases and 6 bromoindirubin, extracted from mollusks, to bind glycogen synthase kinase 3. Studies have