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thus promoting LRP6 phosphorylation and Wnt signaling transduction
and inhibit proliferation and migration of metastatic human breast cancer cells (IC50 ~6 µM)
157(2):289-90
InChiKey: UJLAWZDWDVHWOW-YPMHNXCESA-N
LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 042 thus promoting LRP6 phosphorylation andLY294002, CAS No. 154447 36 6, is a potent and selective small molecule PI3K inhibitor, inhibits PI3K with IC50 of 0. 5 M, 0. 57 M and 0. 97 M, respectively. It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3 kinases in the signal transduction pathways involved in cell migration, proliferation, survival, and metabolism. LY294002 inactivates Akt PKB, consequently inhibiting cell proliferation and inducing apoptosis. It is