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UCHL5 and USP14
InChiKey: BVAHPPKGOOJSPU-UHFFFAOYSA-N
186(7):4234-43
3-{[6-(benzylamino)-9-(propan-2-yl)-9h-purin-2-yl]amino}propan-1-ol
UNC2025 ranol UCHL5 and USP14UNC 2025 is a novel potent and highly orally bioavailable Mer FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco dynamic (PD) studies examining phospho Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC 2025 has similar subnanomolar activity against Flt3, an additional