Tankyrase Inhibitors (TNKS) 22 halin 3 nM-30 nM) induces a

3 nM-30 nM) induces a rightward shift of the orexin-A CRCs with a depression of the agonist efficacy suggesting a clear non-surmountable behavior

InChiKey: PNTVCCRNJOGKGA-QFIPXVFZSA-N

which consists of four pyrrole rings

CD38-IN-78c

Tankyrase Inhibitors (TNKS) 22 halin 3 nM-30 nM) induces aTankyrase Inhibitors (TNKS) 22 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis