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(±)-5'-Chloro-5'-deoxy-ENBA is a selective and high-affinity adenosine A1 receptor agonist with Ki values of 0
C2HF3O2/c1-30(2)27-41(48(60)78)67-52(82)39(19-22-46(76)77)64-49(79)35(15-11-13-24-58)62-51(81)38(18-21-45(74)75)65-53(83)40(23-26-88-10)66-56(86)43(29-32(5)6)69-57(87)47(33(7)8)70-54(84)36(16-12-14-25-59)63-55(85)42(28-31(3)4)68-50(80)37(61-34(9)71)17-20-44(72)73
InChi: InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7
It increases the activity of pSer9-glycogen synthase kinase and insulin degrading enzyme (IDE) and reduces the accumulation of amyloid-β (1-42) (Aβ42) in the rat hippocampal CA1 and CA3 regions in a model of vascular dementia induced by chronic cerebral hypofusion
ALX-1393 27420 (±)-5'-Chloro-5'-deoxy-ENBA is a selective andALX 1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model. Product information CAS Number: 949164 09 4 Molecular Weight: 395. 42 Formula: C23H22FNO4 Chemical Name: (2S) 2 amino 3 {[2 (benzyloxy)phenyl](3 fluorophenyl)methoxy}propanoic acid Smiles: N[C@@H](COC(C1=CC=CC=C1OCC1C=CC=CC=1)C1=CC(F)=CC=C1)C(O)=O InChiKey: ADUSZEGHFWRTQS AIBWNMTMSA N InChi: InChI=1S
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