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Smiles: CC1=CC2=C(C=C1C(=C)C1C=CC(=CC=1)C(O)=O)C(C)(C)CCC2(C)C
The multifaceted roles of USP7: new therapeutic opportunities
InChi: InChI=1S/C19H12F5N5/c1-10-26-15-6-13(20)14(21)7-16(15)29(10)18-9-25-8-17(28-18)27-12-4-2-11(3-5-12)19(22
Epub 2011 Feb 1
AP 1903 - CAS# 195514-63-7 size:2mg solid Smiles: CC1=CC2=C(C=C1C(=C)C1C=CC(=CC=1)C(O)=O)C(C)(C)CCC2(C)CAP 1903, CAS No. 195514 63 7, also known as Rimiducid, is a lipid permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild type FKBP12 with 1000 fold lower affinity. This agent is used to homodimerize the Fv containing drug binding domains of genetically engineered receptors such as the iCD40
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