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857036-77-2 (Cediranib maleate)
05] and a significant effect of KN-62×ZnCl2 treatment interaction [F(1
It was dosed to diabetic ob/ob mice via oral gavage at 3-30 mg/kg once per day for 2 weeks
InChiKey: PXXLQQDIFVPNMP-UHFFFAOYSA-N
GDC-0152 ridol (Alvocidib) 857036-77-2 (Cediranib maleate)GDC 0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC 0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are
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