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and has demonstrated oral bioavailability in multiple species
25(2):226-42
Molecular Weight: 386
PubMed PMID: 23388106
MI-2 - Menin-MLL Inhibitor. CAS# 1271738-62-5 60033 and has demonstrated oral bioavailabilityMI 2, CAS No. 1271738 62 5, is a potent and specific Menin MLL inhibitor with an IC50 ~446 nM. It specifically binds to Menin and inhibits Menins interaction with MLL fusion proteins in cells. It can effectively reverse MLL fusion proteinmediated leukemic transformation by downregulating the expression of target genes downstream of MLL fusion protein oncogenic activity. MI 2 is a new tool for better understanding MLL mediated leukemogenesis and
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