CDK9-IN-1 - CAS# 1415559-43-1 pazide Maleate CAS Number: 872573-93-8

CAS Number: 872573-93-8

21561-09-1

Smiles: COC1=C(C(F)=CC2=C1N(C=C(C(O)=O)C2=O)C1CC1)N1C[C@@H]2CCCN[C@@H]2C1

Smiles: NC1=NC(Cl)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F

CDK9-IN-1 - CAS# 1415559-43-1 pazide Maleate CAS Number: 872573-93-8CDK9 inhibitor is a small molecule selective inhibitor of CDK9 (cyclin dependent kinase 9) with IC50 value of 39 nM. CDKs are a group of serine threonine kinases and are widely spread in all known eukaryotes. CDKs are activated through binding to cyclins and forming heterodimers. In the dimer, CDK acts as a catalytic subunit and phosphorylates the down stream proteins such as nuclear lamina protein, nucleolin and histone H1. Through this way, CDKs